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Clinical Peer-reviewed Research Publication:

Showing the Importance to Overcome Fear - Get out of the Fight & Flight Response in the Recovery and Prevention of Breast Cancer

Vitam Horm. 2013;93:263-76.doi: 10.1016/B978-0-12-416673-8.00011-3.

Beta-endorphin neuron regulates stress response and innate immunity to prevent breast cancer growth and progression.
Sarkar DK, Zhang C.SourceEndocrinology Program and Department of Animal Sciences, Rutgers, The State University of New Jersey, NewBrunswick, New Jersey, USA. sarkar@aesop.rutgers.edu
Abstract

Body and mind interact extensively with each other to control health. Emerging evidence suggests that chronic neuro behavioral stress can promote various tumor growth and progression. The biological reaction to stress involves a chemical cascade initiated within the central nervous system and extends to the periphery, encompassing the immune,endocrine, and autonomic systems. Activation of sympathetic nervous system,such as what happens in the "fight or flight" response, down regulates tumor-suppressive genes,inhibits immune function, and promotes tumor growth. On the other hand, an optimistic attitude or psychological intervention helps cancer patients to survive longer via increase in β-endorphin neuronal suppression of stress hormone levels and sympathetic outflows and activation of parasympathetic control of tumor suppressor gene and innate immune cells to destroy and clear tumor cells.



The Importance to Re-write Limited Beliefs
Recent advances in cellular science are heralding a​n important evolutionary turning point.For almost fifty years we have held the illusion that our health were pre-programmed in our genes, a concept referred to as Genetic Determinacy. “Rather than genes, it is our beliefs that control our lives” according to Epigenetics by Bruce Lipton Ph.D. According to Dr. Andrew Doan MD, Ph.D.Research has shown that 2/3 is based on genetics and 1/3 is based on experiences. But the 1/3 has great influence on clinical outcomes. If you're born with a point mutation in a crucial gene... Epigenetics will not correct that…But MOST diseases are not because of inborn errors."



Clinical Peer-reviewed Research Publication:
Showing Benefits for Positive Thought Treatment (Autosuggestion of Positive Affirmations/Yoga Mantras) coupled with Expectations and Images Absorbed by the Subconscious

http://www.ncbi.nlm.nih.gov/pubmed/?term=autosuggestion
​Perspect Biol Med. 2012 Winter;55(1):43-58. doi: 10.1353/pbm.2012.0005.
The placebo effect: how the subconscious fits in.
Mommaerts JL, Devroey D.SourceDepartment of General Practice, Faculty of Medicine, Free University of Brussels, Brussels, Belgium.
jean.luc.mommaerts@pandora.be
Abstract
​The placebo effect is very well known, being replicated in many scientific studies. At the same time, its exact mechanisms still remain unknown. Quite a few hypothetical explanations for the placebo effect have been suggested, including faith, belief, hope, classical conditioning, conscious/subconscious expectation, endorphins, and the meaning response. This article argues that all these explanations may boil down to autosuggestion, in the sense of "communication with the subconscious." An important implication of this is that the placebo effect can in principle be used effectively without the placebo itself, through a direct use of autosuggestion. The benefits of such a strategy are clear: fewer side effects from medications, huge cost savings, no deception of patients, relief of burden on the physician's time, and healing in domains where medication or other therapies are problematic. Coué graduated with a degree in pharmacology in 1876 and worked as an apothecary at Troyes from 1882 to 1910. When he began working at Troyes, he quickly discovered what later came to be known as the placebo effect. He observed that his patients who used his mantra-like conscious suggestion, "Every day, in every way, I'm getting better and better", (French: Tous les jours à tous points de vue je vais de mieux en mieux), replacing their "thought of illness" with a new "thought of cure," could augment their medication plan. According to Coué, repeating words or images enough times causes the "subconscious" to absorb them.



Clinical Peer-reviewed Research Publication:
Showing Benefits of Positive Thought (hypno-suggestive methods) in Cancer Treatment, with and without Chemo/Radiation
http://en.wikipedia.org/wiki/Autosuggestion
MagyOnkol.2011 Mar;55(1):22-31. doi: MagyOnkol.2011.55.1.22. Epub 2011 Mar 31.[Possibilities of hypnosis and hypnosuggestive methods in oncology].[Article in Hungarian]Jakubovits E.SourceAlapozó Egészségtudományi Intézet, Semmelweis Egyetem Egészségtudományi Kar, Morfológiai és Fiziológiai Tanszék, Budapest.
jakedit@se-etk.hu
Abstract
Fear of death, pain, or the recurrence of the illness of tumor patients can narrow their attention to a point where a spontaneous altered state of consciousness occurs. In these cases hypnosis either in formal psychotherapy or embedded into the everyday communication with the physician can effectively complement other already known medical and psychological techniques. Although numerous studies have reported the beneficial physical and mental changes induced by hypnosis, for a long time there were not enough research to affect evidence-based medicine. New studies meeting the most rigorous methodological standards, new reviews and the characteristics of hypnosis shown by neuroimaging techniques support the acceptance of this method. Hypnosis is used and studied with adult and child tumor patients alike mostly in the areas of anxiety, pain, nausea, vomiting, quality of life, mood amelioration, immune system and hot flushes. Most of the assays describe hypnosis as an empirically validated treatment technique that in most cases surpass attention diversion, coping trainings, cognitive behavior and relaxation techniques and other regular treatments. In this paper we review these observations.



Clinical Peer-reviewed Research Publication:
Showing Benefits of using Mental Imagery/Visualization
http://www.ncbi.nlm.nih.gov/pubmed/
15338531Ber Wiss. 2004 Jun;27(2):99-108.[The role of imagination in modern medicine].[Article in German]Schott H.
​Abstract
In Renaissance and early modern times, the concept of imagination (Latin imaginatio) was essential for the (natural) philosophical explanation of magic processes, especially in the anthropology of Paracelsus. He assumed that imagination was a natural vital power including cosmic, mental, phychical, and physical dimensions. The Paracelsians criticized traditional humor pathology ignoring their theory of' 'natural magic'. On the other hand, they were criticized by their adversaries as charlatans practicing 'black magic'. About 1800, in between enlightenment and romanticism, the healing concept of, animal magnetism' (Mesmerism) evoked an analogous debate, whether, magnetic' phenomena originated from a real (physical) power (so-called, fluidum') or were just due to fantasy or imagination (German Einbildungskraft). At the end of the 19th century, the French internist Hippolyte Bernheim created-against the background of medical hypnosis (hypnotism') as a consequence of Mesmerism - his theory of suggestion and autosuggestion: a new paradigm of psychological respectively psychosomatic medicine, which became the basis for the concept of, placebo' in modern biomedicine. From now on, all the effects of, alternative medicine' could easily be explained by the, placebo-effect', more or less founded - at least unconsciously - on fraud.



Clinical Peer-reviewed Research Publication:

Showing the need for Stress Reduction (overcoming fear) and Self-Regulation … in Oncology, Stroke, Vascular Dementia, Cardiovascular Disease, Obesity, Osteoporosis and Diabetes

REFERENCE Dean Ornish et al.

Effect of comprehensive lifestyle changes on telomerase activity and telomere length in men with biopsy-proven low-risk prostate cancer: 5-year follow-up of a descriptive pilot study.

The Lancet Oncology, 17 September 2013 DOI: 10.1016/S1470-2045(13)70366-8

Lifestyle Changes May Lengthen Telomeres, a Measure of Cell Aging

A small pilot study shows for the first time that changes in diet, exercise, stress management and social support may result in longer telomeres, the parts of chromosomes that affect aging.It is the first controlled trial to show that any intervention might lengthen telomeres over time.The study will be published online on Sept. 16, 2013 in The Lancet Oncology. The study was conducted by scientists at UC San Francisco and the Preventive Medicine Research Institute, a nonprofit public research institute in Sausalito, Calif. that investigates the effect of diet and lifestyle choices on health and disease.


The researchers say they hope the results will inspire larger trials to test the validity of the findings. "Our genes, and our telomeres, are not necessarily our fate," said lead author Dean Ornish, MD, UCSF clinical professor of medicine, and founder and president of the Preventive Medicine Research Institute.

"So often people think 'Oh, I have bad genes, there's nothing I can do about it,'" Ornish said. "But these findings indicate that telomeres may lengthen to the degree that people change how they live.

Research indicates that longer telomeres are associated with fewer illnesses and longer life." Telomeres are the protective caps on the ends of chromosomes that affect how quickly cells age. They are combinations of DNA and protein that protect the ends of chromosomes and help them remain stable. As they become shorter, and as their structural integrity weakens, the cells age and die quicker.

In recent years, shorter telomeres have become associated with a broad range of aging-related diseases, including many forms of cancer, stroke, vascular dementia, cardiovascular disease, obesity, osteoporosis and diabetes.

For five years, the researchers followed 35 men with localized, early-stage prostate cancer to explore the relationship between comprehensive lifestyle changes, and telomere length and telomerase activity. All the men were engaged in active surveillance, which involves closely monitoring a patient's condition through screening and biopsies. Ten of the patients embarked on lifestyle changes that included: a plant-based diet (high in fruits, vegetables and unrefined grains, and low in fat and refined carbohydrates); moderate exercise (walking 30 minutes a day, six days a week); stress reduction (gentle yoga-based stretching, breathing, meditation). They also participated in weekly group support.

They were compared to the other 25 study participants who were not asked to make major lifestyle changes. The group that made the lifestyle changes experienced a "significant" increase in telomere length of approximately 10 percent. Further, the more people changed their behavior by adhering to the recommended lifestyle program, the more dramatic their improvements in telomere length, the scientists learned. By contrast, the men in the control group who were not asked to alter their lifestyle had measurably shorter telomeres -- nearly 3 percent shorter -- when the five-year study ended. Telomere length usually decreases over time.

The researchers say the findings may not be limited to men with prostate cancer, and are likely to be relevant to the general population. "We looked at telomeres in the participants' blood, not their prostate tissue," said Ornish.

The new study is a follow up to a similar, three-month pilot investigation in 2008 in which the same participants were asked to follow the same lifestyle program. After three months, the men in the initial study exhibited significantly increased telomerase activity. Telomerase is an enzyme that repairs and lengthens telomeres. The new study was designed to determine if the lifestyle changes would affect telomere length and telomerase activity in these men over a longer time period. "This was a breakthrough finding that needs to be confirmed by larger studies," said co-senior author Peter R. Carroll, MD, MPH, professor and chair of the UCSF Department of Urology."Telomere shortening increases the risk of a wide variety of chronic diseases," Carroll said. "We believe that increases in telomere length may help to prevent these conditions and perhaps even lengthen lifespan."

Other co-authors from UCSF include senior author and Nobel laureate Elizabeth H. Blackburn, PhD, professor of biochemistry and biophysics; Jue Lin, PhD, associate research biochemist; June M. Chan, DSc, associate professor of epidemiology & biostatistics; Elissa Epel, PhD, associate professor of psychiatry; Mark Jesus M. Magbanua, associate specialist; Jennifer Daubenmier and Nancy K. Hills, PhD, associate adjunct professors; and Nita Chainani-Wu, DMD, MPH, PhD, assistant clinical professor.